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Structure of 193290-19-6
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Methyl 4-bromo-2-fluorophenylacetate features a strategically positioned bromo and fluoro substituent on the phenyl ring, enabling selective functionalization in cross-coupling reactions. The ester group facilitates downstream transformations, while the halogen pattern enhances reactivity in palladium-catalyzed processes. This compound serves as a key intermediate in the synthesis of bioactive molecules and advanced pharmaceutical building blocks.
Methyl 4-bromo-2-fluorophenylacetate serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its orthogonal halogen reactivity. The bromo group facilitates Suzuki, Stille, or Negishi coupling, while the ortho-fluoro substituent enhances metabolic stability and modulates electronic properties. Bench-stable and readily purified by column chromatography, it functions effectively in multi-step syntheses of bioactive heterocycles and API intermediates.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: