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CS-W001157 4
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4-(Pyridin-2-yloxy)benzaldehyde

  • CAS No. 194017-69-1

  • Cat. No. CS-0073746
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-(Pyridin-2-yloxy)benzaldehyde|CS-0073746

Structure of 194017-69-1

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General Information

  • CAS No. 194017-69-1
  • Cat. No. CS-0073746
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₉NO₂
  • Molecular Weight 199.21
  • Synonym(s) 4-(PYRID-2-YLOXY)BENZALDEHYDE
  • SMILES O=CC1=CC=C(C=C1)OC2=CC=CC=N2

Description

4-(Pyridin-2-yloxy)benzaldehyde features a pyridin-2-yl ether linkage that enhances solubility and electronic modulation in synthetic intermediates. The aldehyde group enables direct coupling reactions, while the aromatic scaffold supports efficient transition-metal-catalyzed transformations. This compound serves as a key building block for bioactive heterocycles and functional materials under standard conditions.

Application

4-(Pyridin-2-yloxy)benzaldehyde serves as a versatile building block for the synthesis of functionalized heterocycles and bioactive molecules. Its pyridinyl ether linkage provides enhanced solubility and metabolic stability, while the aldehyde group enables facile derivatization via nucleophilic addition, reductive amination, or condensation reactions. The molecule exhibits good bench stability and is compatible with standard purification techniques, facilitating its use in iterative synthetic sequences and medicinal chemistry campaigns.

Synthesis

  • Route1
    • null|null
      109-09-1
    • p-Hydroxybenzaldehyde Bisoprolol Impurity|CS-0229513
      123-08-0
    • ~%
    • In-stock
      4-(Pyridin-2-yloxy)benzaldehyde|CS-0073746
      194017-69-1

    References

    • WO2006/31764 A2, ; Page/Page column 10-12 ;
  • Route2
    • null|null
      109-04-6
    • p-Hydroxybenzaldehyde Bisoprolol Impurity|CS-0229513
      123-08-0
    • ~95%
    • In-stock
      4-(Pyridin-2-yloxy)benzaldehyde|CS-0073746
      194017-69-1

    References

    • Liu, Xianghao; Fu, Hua; Jiang, Yuyang; Zhao, Yufen Synlett, 2008 , # 2 p. 221 - 224
  • Route3
    • null|null
      372-48-5
    • In-stock
      18-Crown-6-ether|CS-D1202
      17455-13-9
    • p-Hydroxybenzaldehyde Bisoprolol Impurity|CS-0229513
      123-08-0
    • ~%
    • In-stock
      4-(Pyridin-2-yloxy)benzaldehyde|CS-0073746
      194017-69-1

    References

    • US2007 H1, ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   39.19
  • LogP   2.6864
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   3

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