(R)-1-tert-Butyl 3-ethyl piperidine-1,3-dicarboxylate

Name: (R)-1-tert-Butyl 3-ethyl piperidine-1,3-dicarboxylate
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 194726-40-4
Cat. No. CS-W010168
Purity≥98%
MDL No.MFCD07374389

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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(R)-1-tert-Butyl 3-ethyl piperidine-1,3-dicarboxylate|CS-W010168

Structure of 194726-40-4

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Description

(R)-1-tert-Butyl 3-ethyl piperidine-1,3-dicarboxylate is a stereochemically defined piperidine derivative featuring a bench-stable, moisture-tolerant diester scaffold. This chiral building block integrates readily into asymmetric synthesis workflows, offering predictable stereoselectivity in downstream functionalization. The tert-butyl and ethyl ester groups enable selective deprotection and coupling reactions under mild conditions.

Application

(R)-1-tert-Butyl 3-ethyl piperidine-1,3-dicarboxylate serves as a versatile chiral building block in medicinal chemistry, enabling stereoselective synthesis of piperidine-based scaffolds. The protected diamine core exhibits excellent bench stability and functional group tolerance, facilitating downstream transformations including reductive amination, amide coupling, and transition-metal-catalyzed cross-couplings. Its orthogonal protection profile supports sequential derivatization, making it ideal for constructing complex heterocyclic motifs in API development.

General Information

CAS No. 194726-40-4
Cat. No. CS-W010168
Purity ≥98%
MDL No. MFCD07374389
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₃H₂₃NO₄
Molecular Weight 257.33
Synonym(s) Ethyl (R)-1-Boc-nipecotate
SMILES O=C(N1C[C@H](C(OCC)=O)CCC1)OC(C)(C)C

Computational Chemistry Data

TPSA 55.84
LogP 2.1966
H_Acceptors 4
H_Donors 0
Rotatable_Bonds 2

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

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Other Classifications

Building Blocks Functional Group Ester

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Chemical Biology Pharmaceutical Development and Drug Discovery Research Peptide Chemistry Amino Acid Derivatives

Chemical Biology Pharmaceutical Development and Drug Discovery Research Peptide Chemistry Unnatural Amino Acid Derivatives

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Peptide Chemistry Amino Acid Derivatives

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Peptide Chemistry Unnatural Amino Acid Derivatives

Biochemistry Biochemicals and Reagents Amino Acids C-ProtectedAmino Acids

Biochemistry Biochemicals and Reagents Amino Acids N-Protected Amino Acids

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(R)-1-tert-Butyl 3-ethyl piperidine-1,3-dicarboxylate

CAS No. 194726-40-4

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