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Structure of 1960-88-9
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1,3-Bis(4-(trifluoromethyl)phenyl)urea features a rigid, electron-deficient core flanked by two trifluoromethyl-substituted aryl groups, enhancing stability and solubility in polar aprotic solvents. This structure enables robust participation in hydrogen-bonding networks, making it valuable for supramolecular assembly and crystal engineering applications.
1,3-Bis(4-(trifluoromethyl)phenyl)urea serves as a robust scaffold in medicinal chemistry, offering enhanced metabolic stability and lipophilicity due to its perfluorinated aryl substituents. The urea linkage enables hydrogen bonding interactions in target binding, while the sterically hindered structure imparts excellent bench stability and compatibility with diverse reaction conditions. It functions effectively as a building block for bioactive heterocycles and protein-binding motifs in lead optimization campaigns.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319
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Precautionary Statements : P264-P280-P302+P352-P362
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Lot numbers can be found on the outside label of a product: