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CS-W001157 4
Total: USD 88.00

8-Ethylquinoline

  • CAS No. 19655-56-2

  • Cat. No. CS-0152545
  • Purity≥98%
  • MDL No.MFCD00040688

*For research and further manufacturing use only, not for direct human use.

8-Ethylquinoline|CS-0152545

Structure of 19655-56-2

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General Information

  • CAS No. 19655-56-2
  • Cat. No. CS-0152545
  • Purity ≥98%
  • MDL No. MFCD00040688
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₁N
  • Molecular Weight 157.21
  • Synonym(s) 8-ETHYL QUINOLINE
  • SMILES CCC1=C2C(=CC=C1)C=CC=N2

Description

8-Ethylquinoline is a bench-stable, electron-rich heterocycle featuring a strategically positioned ethyl group that enhances solubility and modulates electronic properties. This compound serves as a critical ligand in transition metal catalysis and integrates readily into functional materials due to its robust aromatic core and tailored steric profile.

Application

8-Ethylquinoline serves as a versatile heterocyclic building block in medicinal chemistry and catalysis, offering enhanced lipophilicity and metabolic stability compared to unsubstituted quinoline. Its ethyl group at the 8-position improves solubility and facilitates downstream functionalization via electrophilic substitution or transition-metal-catalyzed coupling reactions. The compound exhibits good bench stability and is compatible with common purification methods, making it well-suited for iterative synthesis of bioactive molecules and ligand development.

Synthesis

  • Route1
    • null|null
      578-54-1
    • In-stock
      Glycerol|CS-6964
      56-81-5
    • ~85%
    • In-stock
      8-Ethylquinoline|CS-0152545
      19655-56-2

    References

    • Lu, Biao; Li, Chaoqun; Zhang, Liming Journal of the American Chemical Society, 2010 , vol. 132, # 40 p. 14070 - 14072
  • Route2
    • null|null
      611-32-5
    • null|null
      823-96-1
    • ~78%
    • In-stock
      8-Ethylquinoline|CS-0152545
      19655-56-2

    References

    • BRANDEIS UNIVERSITY MS134 Patent: WO2008/24953 A2, 2008 ; Location in patent: Page/Page column 6; 62; 71 ;
  • Route3
    • null|null
      578-54-1
    • ~%
    • In-stock
      8-Ethylquinoline|CS-0152545
      19655-56-2

    References

    • Glenn; Bailey Journal of the American Chemical Society, 1941 , vol. 63, p. 639

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.7972
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

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