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Structure of 197507-22-5
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Methyl 2-fluoro-4-hydroxybenzoate features a strategically positioned fluorine atom and hydroxyl group on the aromatic ring, enabling precise electronic tuning and enhanced solubility in polar solvents. This combination facilitates direct incorporation into bioactive scaffolds and supports efficient derivatization under standard coupling conditions.
Methyl 2-fluoro-4-hydroxybenzoate serves as a versatile building block in medicinal chemistry and synthetic organic chemistry, enabling the construction of bioactive heterocycles and pharmaceutical intermediates. The ortho-fluoro and para-hydroxy groups provide complementary reactivity for Suzuki-Miyaura coupling, nucleophilic substitution, and directed ortho-metalation. Its bench-stable nature, combined with straightforward purification via recrystallization, supports reliable use in multi-step syntheses and scale-up processes.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: