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CS-W001157 4
Total: USD 88.00

Methyl 2-fluoro-4-hydroxybenzoate

  • CAS No. 197507-22-5

  • Cat. No. CS-W008400
  • Purity≥98%
  • MDL No.MFCD09038282
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Methyl 2-fluoro-4-hydroxybenzoate|CS-W008400

Structure of 197507-22-5

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Description

Methyl 2-fluoro-4-hydroxybenzoate features a strategically positioned fluorine atom and hydroxyl group on the aromatic ring, enabling precise electronic tuning and enhanced solubility in polar solvents. This combination facilitates direct incorporation into bioactive scaffolds and supports efficient derivatization under standard coupling conditions.

Application

Methyl 2-fluoro-4-hydroxybenzoate serves as a versatile building block in medicinal chemistry and synthetic organic chemistry, enabling the construction of bioactive heterocycles and pharmaceutical intermediates. The ortho-fluoro and para-hydroxy groups provide complementary reactivity for Suzuki-Miyaura coupling, nucleophilic substitution, and directed ortho-metalation. Its bench-stable nature, combined with straightforward purification via recrystallization, supports reliable use in multi-step syntheses and scale-up processes.

General Information

  • CAS No. 197507-22-5
  • Cat. No. CS-W008400
  • Purity ≥98%
  • MDL No. MFCD09038282
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₇FO₃
  • Molecular Weight 170.14
  • Synonym(s) 2-Fluoro-4-hydroxybenzoic acid methyl ester
  • SMILES FC1=C(C(=O)OC)C=CC(=C1)O

Computational Chemistry Data

  • TPSA   46.53
  • LogP   1.3179
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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