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Structure of 1977-72-6
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5-Fluoro-1H-benzo[d]imidazole features a fluorinated benzene ring fused to an imidazole core, delivering enhanced electron-withdrawing character and improved metabolic stability. This structural motif enables direct incorporation into bioactive scaffolds for medicinal chemistry applications, particularly in kinase inhibitors and CNS-targeted compounds. The fluorine substituent enhances membrane permeability and modulates electronic properties without significant steric perturbation.
5-Fluoro-1H-benzo[d]imidazole serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to bioactive scaffolds through standard coupling and functionalization reactions. Its fluorinated aromatic core enhances metabolic stability and modulates electronic properties, while the imidazole nitrogen offers predictable coordination and hydrogen-bonding capability. Bench-stable and readily purified, it functions effectively in Pd-catalyzed cross-couplings, electrophilic substitutions, and as a key motif in kinase inhibitor and CNS-targeted compound development.
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GHS Pictogram :
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GHS No : GHS05,GHS07
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Signal Word : Danger
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UN#: 1759
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Class : 8
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Packing Group : Ⅲ
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Hazard Statements : H302-H318
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Precautionary Statements : P264-P270-P280-P280-P501
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Lot numbers can be found on the outside label of a product: