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CS-W001157 4
Total: USD 88.00

5-Fluoro-1H-benzo[d]imidazole

  • CAS No. 1977-72-6

  • Cat. No. CS-W005827
  • Purity≥98%
  • MDL No.MFCD00792438
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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*For research and further manufacturing use only, not for direct human use.

5-Fluoro-1H-benzo[d]imidazole|CS-W005827

Structure of 1977-72-6

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Description

5-Fluoro-1H-benzo[d]imidazole features a fluorinated benzene ring fused to an imidazole core, delivering enhanced electron-withdrawing character and improved metabolic stability. This structural motif enables direct incorporation into bioactive scaffolds for medicinal chemistry applications, particularly in kinase inhibitors and CNS-targeted compounds. The fluorine substituent enhances membrane permeability and modulates electronic properties without significant steric perturbation.

Application

5-Fluoro-1H-benzo[d]imidazole serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to bioactive scaffolds through standard coupling and functionalization reactions. Its fluorinated aromatic core enhances metabolic stability and modulates electronic properties, while the imidazole nitrogen offers predictable coordination and hydrogen-bonding capability. Bench-stable and readily purified, it functions effectively in Pd-catalyzed cross-couplings, electrophilic substitutions, and as a key motif in kinase inhibitor and CNS-targeted compound development.

General Information

  • CAS No. 1977-72-6
  • Cat. No. CS-W005827
  • Purity ≥98%
  • MDL No. MFCD00792438
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅FN₂
  • Molecular Weight 136.13
  • Synonym(s) 1H-Benzimidazole,5-Fluoro-
  • SMILES FC1=CC=C2NC=NC2=C1

Computational Chemistry Data

  • TPSA   28.68
  • LogP   1.702
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H318
Precautionary Statements : P264-P270-P280-P280-P501

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