Fmoc-D-Phe(F5)-OH

Name: Fmoc-D-Phe(F5)-OH
Brand: ChemScene
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CAS No. 198545-85-6
Cat. No. CS-0150071
Purity≥98%
MDL No.MFCD00672558

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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Structure of 198545-85-6

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Description

Fmoc-D-Phe(F5)-OH features a fluorinated phenyl ring with five fluorine atoms, enhancing electron deficiency and metabolic stability. This sterically hindered D-amino acid derivative integrates efficiently into peptide chains, offering improved resistance to enzymatic degradation while maintaining solubility under standard coupling conditions.

Application

Fmoc-D-Phe(F5)-OH serves as a key building block in peptide synthesis, enabling the incorporation of fluorinated D-phenylalanine residues with enhanced metabolic stability and conformational rigidity. The trifluoromethyl-substituted aromatic ring improves lipophilicity and bioavailability, while the Fmoc group ensures efficient orthogonal protection for N-terminal control. This derivative exhibits excellent bench stability, compatibility with standard coupling protocols, and facilitates purification via flash chromatography or crystallization.

General Information

CAS No. 198545-85-6
Cat. No. CS-0150071
Purity ≥98%
MDL No. MFCD00672558
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₄H₁₆F₅NO₄
Molecular Weight 477.38
Synonym(s) Fmoc-3-Pentafluorophenyl-D-alanine
SMILES FC1=C(F)C(F)=C(F)C(F)=C1C[C@H](C(O)=O)NC(OCC2C3=CC=CC=C3C4=CC=CC=C42)=O

Computational Chemistry Data

TPSA 75.63
LogP 4.9165
H_Acceptors 3
H_Donors 2
Rotatable_Bonds 6

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H312-H315-H319
Precautionary Statements : P264-P270-P280-P302+P352-P330-P362+P364-P501

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Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Life Science Amino Acids and their Derivatives Phenylalanine and derivatives

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Unnatural Amino Acid Derivatives

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Fmoc-D-Phe(F5)-OH

CAS No. 198545-85-6

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