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Fmoc-Asp-NH2

  • CAS No. 200335-40-6

  • Cat. No. CS-0112610
  • Molecule weight354.36
  • Purity≥95%
  • MDL No.MFCD00151920

*For research and further manufacturing use only, not for direct human use.

Fmoc-Asp-NH2|CS-0112610

Structure of 200335-40-6

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General Information

  • CAS No. 200335-40-6
  • Cat. No. CS-0112610
  • Purity ≥95%
  • MDL No. MFCD00151920
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₉H₁₈N₂O₅
  • Molecular Weight 354.36
  • Synonym(s) None
  • SMILES O=C(O)C[C@H](NC(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O)C(N)=O

Description

Fmoc-Asp-NH2 is a protected aspartic acid derivative featuring a fluorenylmethoxycarbonyl group at the α-amino terminus and a free carboxylic acid at the side chain. This configuration enables direct incorporation into solid-phase peptide synthesis workflows, where the side-chain protection remains stable under standard deprotection conditions. The Fmoc moiety facilitates efficient coupling and selective removal via mild base treatment, streamlining sequence assembly.

Application

Fmoc-Asp-NH2 serves as a key building block in solid-phase peptide synthesis, offering orthogonal protection for both the α-amino and side-chain carboxyl groups. The Fmoc group enables mild base-labile deprotection, while the side-chain is protected as a stable tert-butyl ester, facilitating selective functionalization. Its bench-stable, crystalline form simplifies handling and purification, making it ideal for synthesizing complex peptides, including those containing acidic residues or requiring precise sequence control.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H312-H332
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501

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Computational Chemistry Data

  • TPSA   118.72
  • LogP   1.8537
  • H_Acceptors   4
  • H_Donors   3
  • Rotatable_Bonds   6

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