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Structure of 201732-49-2
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This chiral phosphine ligand features a rigid dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin scaffold with sterically demanding 2,6-dimethyl and (1R)-1-phenylethyl substituents, enabling high enantioselectivity in palladium-catalyzed cross-coupling reactions under standard conditions.
(11bS)-2,6-Dimethyl-N,N-bis[(1R)-1-phenylethyl]dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-amine serves as a sterically hindered, chiral phosphine ligand that enables efficient transition-metal-catalyzed cross-coupling reactions. Its rigid, polycyclic framework imparts high thermal stability and excellent functional group tolerance, facilitating reliable performance in palladium-catalyzed Suzuki-Miyaura and Negishi couplings. The ligand’s defined stereochemistry and robustness simplify purification and enhance reproducibility in complex molecule synthesis.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: