1-Bromo-2-chloro-5-fluoro-4-methylbenzene

Name: 1-Bromo-2-chloro-5-fluoro-4-methylbenzene
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 201849-17-4
Cat. No. CS-W002422
Purity≥98%
MDL No.MFCD00143269

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

1-Bromo-2-chloro-5-fluoro-4-methylbenzene|CS-W002422

Structure of 201849-17-4

Size

Price

Quantity

* Please select Quantity before adding items.

Description

1-Bromo-2-chloro-5-fluoro-4-methylbenzene features a densely halogenated aromatic core with orthogonal reactivity, enabling selective cross-coupling in late-stage functionalization. The methyl group enhances lipophilicity and provides a handle for further derivatization. This compound exhibits robust stability under standard bench conditions and integrates seamlessly into complex molecular architectures.

Application

1-Bromo-2-chloro-5-fluoro-4-methylbenzene serves as a versatile ortho-disubstituted aryl building block for palladium-catalyzed cross-coupling reactions. The bromo group enables efficient Suzuki, Stille, and Negishi coupling, while the chloro and fluoro substituents provide orthogonal reactivity and enhanced metabolic stability in medicinal chemistry applications. Bench-stable and compatible with standard purification methods, it facilitates the construction of complex biaryl and heterocyclic scaffolds under mild reaction conditions.

General Information

CAS No. 201849-17-4
Cat. No. CS-W002422
Purity ≥98%
MDL No. MFCD00143269
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₅BrClF
Molecular Weight 223.47
Synonym(s) 4-Bromo-5-chloro-2-fluorotoluene
SMILES Fc1cc(Br)c(cc1C)Cl

Computational Chemistry Data

TPSA 0
LogP 3.55002
H_Acceptors 0
H_Donors 0
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

201849-17-4 sigma201849-17-4 manufacturer201849-17-4 price201849-17-4 structure201849-17-4 SDSbuy 201849-17-4201849-17-4 supplier201849-17-4 uses201849-17-4 molecular weightprice of 201849-17-4201849-17-4 chemical name formula of 201849-17-4

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

1-Bromo-2-chloro-5-fluoro-4-methylbenzene

CAS No. 201849-17-4

Recommended Products