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Structure of 202982-67-0
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4-Chloro-3-fluoroiodobenzene features a trifunctional aryl scaffold with orthogonal reactivity, enabling seamless integration into cross-coupling cascades. The iodine moiety facilitates efficient Pd-catalyzed transformations, while the chloro and fluoro substituents offer complementary handles for sequential functionalization under mild conditions. This compound serves as a strategic intermediate in the synthesis of bioactive heterocycles and advanced pharmaceutical building blocks.
4-Chloro-3-fluoroiodobenzene serves as a versatile building block in transition-metal-catalyzed cross-coupling reactions, enabling efficient construction of biaryl and heteroaryl architectures. Its orthogonal halogen reactivity profile—where iodine undergoes rapid coupling while chlorine remains inert under standard conditions—facilitates sequential functionalization strategies. The molecule exhibits excellent bench stability and is compatible with palladium- and nickel-catalyzed processes, simplifying purification and enhancing reproducibility in medicinal chemistry and materials synthesis workflows.
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: