Lot numbers can be found on the outside label of a product:
2,2-Dimethyl-1-(thiophen-2-yl)propan-1-one
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CAS No. 20409-48-7
- Cat. No. CS-0358925
- Purity≥98%
- MDL No.None
*For research and further manufacturing use only, not for direct human use.
Structure of 20409-48-7
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General Information
- CAS No. 20409-48-7
- Cat. No. CS-0358925
- Purity ≥98%
- MDL No. None
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₉H₁₂OS
- Molecular Weight 168.26
- Synonym(s) 2-(Trimethylacetyl)thiophene
- SMILES CC(C)(C)C(=O)C1=CC=CS1
Description
This thiophene-bearing ketone features a sterically hindered α-carbon, enhancing stability and facilitating selective transformations. The conjugated thiophenyl group imparts electronic delocalization, enabling efficient coupling in cross-coupling reactions and serving as a robust scaffold for synthetic intermediates in pharmaceutical and materials chemistry.
Application
2,2-Dimethyl-1-(thiophen-2-yl)propan-1-one serves as a versatile building block in heterocyclic synthesis, enabling efficient construction of thiophene-fused scaffolds. Its α,α-dimethyl ketone functionality enhances bench stability and facilitates direct functionalization via enolization or nucleophilic addition. The molecule exhibits excellent compatibility with standard coupling protocols and functions as a key intermediate in the development of bioactive compounds, particularly those requiring sterically hindered aryl ketone motifs.
Synthesis
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Route1
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188290-36-0 -
3282-30-2
- ~93%
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In-stock
20409-48-7
References
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Meshram; Reddy, Gondi Sudershan; Muralidhar Reddy; Yadav Synthetic Communications, 1998 , vol. 28, # 12 p. 2203 - 2206
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Route2
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In-stock
75-98-9 - ~%
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In-stock
20409-48-7
References
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Tetrahedron, , vol. 52, # 45 p. 14297 - 14310
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Route3
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188290-36-0
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In-stock
75-98-9
- ~%
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In-stock
20409-48-7
References
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Zhurnal Obshchei Khimii, , vol. 29, p. 3873,3878; engl. Ausg. S. 3831, 3836 Zhurnal Obshchei Khimii, , vol. 26, p. 3341,3344; engl. Ausg. S. 3717 Zhurnal Obshchei Khimii, , vol. 29, p. 3873,3878; engl. Ausg. S. 3831, 3836
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H317
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Precautionary Statements : P261-P264-P270-P272-P280-P302+P352-P330-P362+P364-P501
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Quality Control
Computational Chemistry Data
- TPSA 17.07
- LogP 2.9769
- H_Acceptors 2
- H_Donors 0
- Rotatable_Bonds 1
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