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CS-W001157 4
Total: USD 88.00

3-Bromoquinoline-6-carboxylic acid

  • CAS No. 205114-14-3

  • Cat. No. CS-0139219
  • Purity≥98%
  • MDL No.MFCD18086942
  • HazMat Fee +

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

3-Bromoquinoline-6-carboxylic acid|CS-0139219

Structure of 205114-14-3

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Description

3-Bromoquinoline-6-carboxylic acid features a bromine substituent at the 3-position and a carboxylic acid group at the 6-position of the quinoline core. This combination enables direct functionalization in cross-coupling reactions and facilitates conjugation to biomolecules or polymer backbones via amide bond formation. The electron-deficient quinoline scaffold enhances reactivity in transition metal-catalyzed transformations, while the bench-stable carboxylic acid serves as a versatile handle for downstream derivatization under standard conditions.

Application

3-Bromoquinoline-6-carboxylic acid serves as a versatile building block for the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its bromo group enables palladium-catalyzed cross-coupling reactions, while the carboxylic acid functionality supports derivatization via amide formation or esterification. The molecule exhibits good bench stability and facilitates efficient purification, making it well-suited for iterative synthetic sequences in medicinal chemistry and process development.

General Information

  • CAS No. 205114-14-3
  • Cat. No. CS-0139219
  • Purity ≥98%
  • MDL No. MFCD18086942
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₆BrNO₂
  • Molecular Weight 252.06
  • Synonym(s) 3-Bromo-6-quinolinecarboxylic acid
  • SMILES O=C(C1=CC=C2N=CC(Br)=CC2=C1)O

Computational Chemistry Data

  • TPSA   50.19
  • LogP   2.6955
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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