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CS-W001157 4
Total: USD 88.00

1-Boc-2-Hydroxymethyl-piperazine

  • CAS No. 205434-75-9

  • Cat. No. CS-B0417
  • Molecule weight216.28
  • Purity≥96%
  • MDL No.MFCD07772091

*For research and further manufacturing use only, not for direct human use.

1-Boc-2-Hydroxymethyl-piperazine|CS-B0417

Structure of 205434-75-9

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General Information

  • CAS No. 205434-75-9
  • Cat. No. CS-B0417
  • Purity ≥96%
  • MDL No. MFCD07772091
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₂₀N₂O₃
  • Molecular Weight 216.28
  • Synonym(s) Tert-butyl 2-(hydroxymethyl)piperazine-1-carboxylate
  • SMILES O=C(OC(C)(C)C)N1C(CO)CNCC1

Description

1-Boc-2-Hydroxymethyl-piperazine features a protected piperazine core with a hydroxymethyl side chain, enabling selective derivatization in synthetic workflows. The Boc group ensures stability under basic conditions while the pendant hydroxyl facilitates further functionalization through oxidation or coupling reactions. This scaffold integrates readily into bioactive molecule design and is compatible with standard peptide and small-molecule synthesis protocols.

Application

1-Boc-2-hydroxymethylpiperazine serves as a versatile building block in medicinal chemistry, enabling efficient access to piperazine-based scaffolds. The Boc group provides orthogonal protection for the nitrogen, while the pendant hydroxymethyl functionality offers a handle for further derivatization via oxidation or substitution. Its bench-stable nature and compatibility with standard coupling conditions facilitate integration into multi-step syntheses of API candidates and functionalized heterocycles.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   61.8
  • LogP   0.1876
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   1

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