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CS-W001157 4
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Methyl 7-methoxy-4-oxo-1,4-dihydroquinoline-6-carboxylate

  • CAS No. 205448-65-3

  • Cat. No. CS-0041771
  • Purity≥98%
  • MDL No.MFCD13192255

*For research and further manufacturing use only, not for direct human use.

Methyl 7-methoxy-4-oxo-1,4-dihydroquinoline-6-carboxylate|CS-0041771

Structure of 205448-65-3

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General Information

  • CAS No. 205448-65-3
  • Cat. No. CS-0041771
  • Purity ≥98%
  • MDL No. MFCD13192255
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₁NO₄
  • Molecular Weight 233.22
  • Synonym(s) Methyl 7-Methoxy-4-oxo-1
  • SMILES O=C(C1=CC2=C(NC=CC2=O)C=C1OC)OC

Description

Methyl 7-methoxy-4-oxo-1,4-dihydroquinoline-6-carboxylate features a fused quinoline core with electron-rich methoxy and carbonyl functionalities, enabling direct integration into synthetic routes for bioactive heterocycles. The methyl ester group supports convenient derivatization under standard conditions. This bench-stable compound serves as a key intermediate in medicinal chemistry campaigns targeting kinase inhibitors and antimicrobial agents.

Application

Methyl 7-methoxy-4-oxo-1,4-dihydroquinoline-6-carboxylate serves as a versatile scaffold for the synthesis of quinoline-based heterocycles and bioactive molecules. Its ortho-quinone-like reactivity enables efficient palladium-catalyzed cross-couplings, while the methoxy and ester groups provide orthogonal handles for further functionalization. The compound exhibits excellent bench stability and facilitates straightforward purification, making it well-suited for iterative medicinal chemistry campaigns and process development workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   68.39
  • LogP   1.3233
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   2

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