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Structure of 205526-26-7
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Fmoc-Phe(2-F)-OH features a fluorinated phenyl ring at the ortho position, enhancing electron-withdrawing character and improving metabolic stability. This derivative integrates readily into peptide chains under standard coupling conditions, offering enhanced solubility and reduced aggregation during synthesis.
Fmoc-Phe(2-F)-OH serves as a valuable building block in peptide synthesis, offering enhanced metabolic stability through the ortho-fluorinated phenylalanine residue. The Fmoc group enables efficient orthogonal protection for amine-directed coupling, while the 2-fluoro substitution provides steric and electronic modulation without compromising solubility or handling. This derivative facilitates incorporation of fluorinated aromatic side chains into peptides, supporting structure-activity studies and improving proteolytic resistance in bioactive sequences.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: