Fmoc-L-β-indanylglycine

Name: Fmoc-L-β-indanylglycine
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CAS No. 205526-39-2
Cat. No. CS-0312462
Molecule weight413.47
Purity≥97%
MDL No.MFCD00672561

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 205526-39-2

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General Information

CAS No. 205526-39-2
Cat. No. CS-0312462
Purity ≥97%
MDL No. MFCD00672561
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₆H₂₃NO₄
Molecular Weight 413.47
Synonym(s) Fmoc-L-2-indanylglycine
SMILES OC([C@H](C1CC2=CC=CC=C2C1)NC(OCC3C4=CC=CC=C4C5=CC=CC=C53)=O)=O

Description

Fmoc-L-β-indanylglycine integrates a sterically hindered β-indanyl group with a robust Fmoc-protected amino acid scaffold, enabling efficient incorporation into peptide sequences under standard coupling conditions. This derivative enhances backbone rigidity and modulates conformational dynamics in synthetic peptides.

Application

Fmoc-L-β-indanylglycine serves as a valuable building block in peptide synthesis, offering a rigid β-indanyl side chain that enhances conformational control in bioactive peptides. The Fmoc group enables efficient N-terminal protection and orthogonal deprotection, while the indanyl moiety provides steric bulk and metabolic stability. This compound facilitates the incorporation of non-natural amino acids with improved pharmacokinetic profiles, particularly in peptidomimetic drug discovery.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 75.63
LogP 4.3933
H_Acceptors 3
H_Donors 2
Rotatable_Bonds 5

Other Classifications

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Life Science Amino Acids and their Derivatives Alanine and derivatives

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Unnatural Amino Acid Derivatives

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Fmoc-L-β-indanylglycine

CAS No. 205526-39-2

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