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CS-W001157 4
Total: USD 88.00

Mal-amido-PEG3-acid

  • CAS No. 2055353-75-6

  • Cat. No. CS-0167709
  • Purity≥98%
  • MDL No.None
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Mal-amido-PEG3-acid|CS-0167709

Structure of 2055353-75-6

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Description

Mal-amido-PEG3-acid is a bifunctional linker featuring a maleimide group conjugated to a PEG3 spacer terminated with a carboxylic acid. This design enables site-specific bioconjugation via thiol-Michael addition, while the hydrophilic PEG chain enhances solubility and reduces non-specific binding. The terminal carboxyl group facilitates further coupling reactions under standard activation conditions.

Application

Mal-amido-PEG3-acid serves as a versatile, water-soluble bifunctional linker for conjugation workflows. The maleimide group enables site-specific thiol-Click coupling under physiological conditions, while the PEG3 spacer provides enhanced solubility and reduced non-specific binding. The terminal carboxylic acid facilitates amide coupling with primary amines, enabling efficient construction of dual-functional bioconjugates. Bench-stable and compatible with standard purification methods, it supports robust synthesis of antibody-drug conjugates, peptide-protein hybrids, and targeted delivery systems.

General Information

  • CAS No. 2055353-75-6
  • Cat. No. CS-0167709
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₆H₂₄N₂O₈
  • Molecular Weight 372.37
  • Synonym(s) None
  • SMILES O=C(O)CCOCCOCCOCCNC(CCN1C(C=CC1=O)=O)=O

Computational Chemistry Data

  • TPSA   131.47
  • LogP   -1.0578
  • H_Acceptors   7
  • H_Donors   2
  • Rotatable_Bonds   15

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362+P364

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