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CS-W001157 4
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(R)-2-((tert-Butoxycarbonyl)amino)-3-mercaptopropanoic acid

  • CAS No. 20887-95-0

  • Cat. No. CS-W014733
  • Purity≥97%
  • MDL No.MFCD00065565

*For research and further manufacturing use only, not for direct human use.

(R)-2-((tert-Butoxycarbonyl)amino)-3-mercaptopropanoic acid|CS-W014733

Structure of 20887-95-0

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General Information

  • CAS No. 20887-95-0
  • Cat. No. CS-W014733
  • Purity ≥97%
  • MDL No. MFCD00065565
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₅NO₄S
  • Molecular Weight 221.27
  • Synonym(s) N-Boc-L-cysteine
  • SMILES SC[C@@H](C(O)=O)NC(OC(C)(C)C)=O

Description

This bench-stable, moisture-tolerant amino acid derivative features a protected amine and a reactive thiol group, enabling site-specific conjugation in peptide synthesis. The tert-butoxycarbonyl moiety ensures stability during handling, while the free thiol facilitates efficient coupling reactions under mild conditions.

Synthesis

  • Route1

    References

    • Sato, Seiichi; Futaki, Fumie; Yasuda, Reiko; Eto, Sachise; Suzuki, Yumiko; Tajima, Takaho; Eto, Yuzuru; Tahara, Yuki Patent: US2012/282386 A1, 2012 ; Location in patent: Page/Page column 15 ; US 20120282386 A1
  • Route2

    References

    • Bissolino, Pierluigi; Alpegiani,, Marco; Borghi, Daniela; Perrone, Ettore; Franceschi, Giovanni Heterocycles, 1993 , vol. 36, # 7 p. 1529 - 1539
  • Route3

    References

    • Babu, S.N. Narendra; Srinivasa; Santhosh; Gowda, D. Channe Journal of Chemical Research, 2004 , # 1 p. 66 - 67

Safety Information

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GHS Pictogram :
GHS No : GHS05,GHS07,GHS09
Signal Word : Danger
UN#: 3077
Class : 9
Packing Group : Ⅲ
Hazard Statements : H315-H318-H335-H411
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P501

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Computational Chemistry Data

  • TPSA   75.63
  • LogP   0.8941
  • H_Acceptors   4
  • H_Donors   3
  • Rotatable_Bonds   3

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