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CS-W001157 4
Total: USD 88.00

Fmoc-β-HoAsp(OtBu)-OH

  • CAS No. 209252-17-5

  • Cat. No. CS-W011640
  • Purity≥98%
  • MDL No.MFCD01862860

*For research and further manufacturing use only, not for direct human use.

Fmoc-β-HoAsp(OtBu)-OH|CS-W011640

Structure of 209252-17-5

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General Information

  • CAS No. 209252-17-5
  • Cat. No. CS-W011640
  • Purity ≥98%
  • MDL No. MFCD01862860
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₄H₂₇NO₆
  • Molecular Weight 425.47
  • Synonym(s) None
  • SMILES O=C(C[C@H](CC(OC(C)(C)C)=O)NC(OCC1C2=C(C=CC=C2)C3=C1C=CC=C3)=O)O

Description

Fmoc-β-HoAsp(OtBu)-OH is a protected aspartic acid derivative featuring a β-hydroxy side chain and a tert-butyl ester group, enabling selective incorporation into peptide sequences. This moiety delivers enhanced solubility and stability under standard coupling conditions, facilitating efficient solid-phase synthesis of complex peptides with hydroxylated residues.

Application

Fmoc-β-HoAsp(OtBu)-OH serves as a key building block for the synthesis of peptide libraries and cyclic peptides, enabling site-specific incorporation of β-hydroxyaspartic acid residues. The Fmoc group provides efficient orthogonal protection for amine functionality, while the OtBu ester offers stable yet cleavable carboxyl protection under standard conditions. This derivative exhibits excellent bench stability and facilitates straightforward purification, making it well-suited for solid-phase peptide synthesis and the construction of complex bioactive scaffolds.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   101.93
  • LogP   4.1002
  • H_Acceptors   5
  • H_Donors   2
  • Rotatable_Bonds   7

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