Fmoc-Phe(2-I)-OH

Name: Fmoc-Phe(2-I)-OH
Brand: ChemScene
Availability: InStock
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CAS No. 210282-32-9
Cat. No. CS-0137320
Purity≥98%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Description

Fmoc-Phe(2-I)-OH features a para-iodinated phenylalanine derivative with a fluorenylmethoxy carbonyl (Fmoc) protecting group. This electron-deficient aromatic moiety enhances coupling efficiency in solid-phase peptide synthesis, while the iodine substituent enables downstream functionalization via cross-coupling reactions. The compound exhibits excellent stability under standard handling conditions.

Application

Fmoc-Phe(2-I)-OH serves as a valuable building block in peptide synthesis, enabling the incorporation of iodinated phenylalanine residues. The ortho-iodo substitution provides a versatile handle for subsequent transition-metal-catalyzed functionalization, including cross-coupling reactions. Its stability under standard Fmoc-based solid-phase synthesis conditions and ease of purification make it well-suited for the construction of complex peptide architectures and bioactive scaffolds.

General Information

CAS No. 210282-32-9
Cat. No. CS-0137320
Purity ≥98%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₄H₂₀INO₄
Molecular Weight 513.32
Synonym(s) Fmoc-Phe(3-I)-Oh
SMILES O=C(O)[C@H](CC1=CC=CC=C1I)NC(OCC2C3=C(C4=C2C=CC=C4)C=CC=C3)=O

Computational Chemistry Data

TPSA 75.63
LogP 4.8256
H_Acceptors 3
H_Donors 2
Rotatable_Bonds 6

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Iodide

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Life Science Amino Acids and their Derivatives Phenylalanine and derivatives

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Unnatural Amino Acid Derivatives

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Fmoc-Phe(2-I)-OH

CAS No. 210282-32-9

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