Fmoc-Phe(3-COOtBu)-OH

Name: Fmoc-Phe(3-COOtBu)-OH
Brand: ChemScene
Availability: InStock
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CAS No. 210282-33-0
Cat. No. CS-0439312
Purity≥98%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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*For research and further manufacturing use only, not for direct human use.

Structure of 210282-33-0

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Description

Fmoc-Phe(3-COOtBu)-OH features a para-substituted phenylalanine derivative with a tert-butyl ester at the meta position, enabling selective deprotection during peptide synthesis. This configuration enhances solubility and stability under standard coupling conditions, facilitating efficient incorporation into challenging sequences.

Application

Fmoc-Phe(3-COOtBu)-OH serves as a key building block in peptide synthesis, enabling the incorporation of ortho-substituted phenylalanine residues with enhanced solubility and reduced aggregation. The tert-butyl ester group provides stable protection for the carboxylic acid under standard coupling conditions, while the Fmoc group ensures efficient orthogonal deprotection. This derivative facilitates reliable N-terminal capping and supports the synthesis of complex peptide architectures, including those involving sterically hindered or aromatic side chains.

General Information

CAS No. 210282-33-0
Cat. No. CS-0439312
Purity ≥98%
MDL No. None
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₉H₂₉NO₆
Molecular Weight 487.54
Synonym(s) None
SMILES C(OC(N[C@@H](CC1=CC(C(OC(C)(C)C)=O)=CC=C1)C(O)=O)=O)C2C=3C(C=4C2=CC=CC4)=CC=CC3

Computational Chemistry Data

TPSA 101.93
LogP 5.1763
H_Acceptors 5
H_Donors 2
Rotatable_Bonds 7

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Other Classifications

Building Blocks Functional Group Fmoc

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Life Science Amino Acids and their Derivatives Phenylalanine and derivatives

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Unnatural Amino Acid Derivatives

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Fmoc-Phe(3-COOtBu)-OH

CAS No. 210282-33-0

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