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CS-W001157 4
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2-Chloro-5,6,7,8-tetrahydro-1,6-naphthyridine

  • CAS No. 210539-05-2

  • Cat. No. CS-0099551
  • Purity≥97%
  • MDL No.MFCD10566728

*For research and further manufacturing use only, not for direct human use.

2-Chloro-5,6,7,8-tetrahydro-1,6-naphthyridine|CS-0099551

Structure of 210539-05-2

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General Information

  • CAS No. 210539-05-2
  • Cat. No. CS-0099551
  • Purity ≥97%
  • MDL No. MFCD10566728
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₉ClN₂
  • Molecular Weight 168.62
  • Synonym(s) 2-Chloro-5,6,7,8-tetrahydro-[1,6]naphthyridin
  • SMILES ClC1=NC2=C(CNCC2)C=C1

Description

This tetrahydro-1,6-naphthyridine derivative features a chlorinated heterocyclic core with enhanced solubility and stability under standard conditions. The fused ring system supports efficient functionalization at the 2-position, enabling direct incorporation into bioactive scaffolds. Ideal for medicinal chemistry campaigns requiring electron-deficient, rigid aromatic platforms with predictable reactivity profiles.

Application

2-Chloro-5,6,7,8-tetrahydro-1,6-naphthyridine serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to bioactive scaffolds through palladium-catalyzed cross-coupling reactions. The chlorinated position facilitates direct functionalization, while the saturated pyridine core offers enhanced solubility and metabolic stability. Its bench-stable nature and compatibility with diverse reaction conditions make it a practical choice for iterative synthesis workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   24.92
  • LogP   1.3807
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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