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Structure of 2117-12-6
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4-Trimethylsilyl-3-butyn-1-ol features a terminal alkyne tethered to a silyl-protected alcohol, enabling reliable conjugate additions and Sonogashira couplings. This bench-stable reagent facilitates efficient C–C bond formation in complex molecule synthesis, particularly in natural product and pharmaceutical applications where orthogonal functional group handling is critical.
4-Trimethylsilyl-3-butyn-1-ol serves as a versatile building block in synthetic organic chemistry, enabling efficient Sonogashira coupling and other palladium-catalyzed transformations. The trimethylsilyl group provides excellent stability and facilitates mild deprotection, while the terminal alkyne functionality supports reliable functionalization. Its bench-stable nature and compatibility with diverse reaction conditions make it ideal for constructing complex molecular architectures in medicinal chemistry and materials science workflows.
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GHS Pictogram :
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GHS No : GHS02,GHS07
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Signal Word : Danger
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UN#: 1993
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Class : 3
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Packing Group : Ⅲ
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Hazard Statements : H226-H315-H319-H335
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Precautionary Statements : P210-P233-P240-P241-P242-P243-P260-P261-P264-P271-P280-P302+P352-P304+P340-P340-P362-P370+P378-P403-P405-P501
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Lot numbers can be found on the outside label of a product: