Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

3-(3-Trifluoromethylphenyl)propionaldehyde

  • CAS No. 21172-41-8

  • Cat. No. CS-B0224
  • Purity≥95%
  • MDL No.MFCD07772918

*For research and further manufacturing use only, not for direct human use.

3-(3-Trifluoromethylphenyl)propionaldehyde|CS-B0224

Structure of 21172-41-8

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 21172-41-8
  • Cat. No. CS-B0224
  • Purity ≥95%
  • MDL No. MFCD07772918
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₉F₃O
  • Molecular Weight 202.18
  • Synonym(s) 3-[3-(trifluoromethyl)phenyl]-propenaldehyde
  • SMILES FC(F)(F)C1=CC(CCC=O)=CC=C1

Description

This trifluoromethyl-substituted aldehyde features a conjugated propionaldehyde chain attached to a meta-trifluoromethylphenyl ring, delivering enhanced electrophilicity and stability. The electron-withdrawing trifluoromethyl group modulates reactivity, enabling selective transformations in synthetic routes. Ideal for constructing bioactive scaffolds and functionalized intermediates in medicinal chemistry.

Application

3-(3-Trifluoromethylphenyl)propionaldehyde serves as a versatile building block for the synthesis of biologically active compounds and functional materials. Its aldehyde functionality enables efficient imine formation, reductive amination, and coupling reactions under standard conditions. The trifluoromethylphenyl group imparts enhanced metabolic stability and lipophilicity, making it valuable in medicinal chemistry lead optimization. Bench-stable and readily purified by distillation or chromatography, it functions reliably in multi-step syntheses.

Synthesis

  • Route1

    References

    • DIPHARMA FRANCIS s.r.l. Patent: US2011/124917 A1, 2011 ; Location in patent: Page/Page column 3-4 ;
  • Route2
    • (E)-3-(3-(Trifluoromethyl)phenyl)acrylaldehyde|CS-0011241
      262268-58-6
    • ~%
    • In-stock
      3-(3-Trifluoromethylphenyl)propionaldehyde|CS-B0224
      21172-41-8

    References

    • WO2006/125026 A2, ; Page/Page column 27 ;
  • Route3
    • 3-(3'-Trifluoromethylphenyl)propionic acid methyl ester|CS-B1547
      294856-02-3
    • ~%
    • In-stock
      3-(3-Trifluoromethylphenyl)propionaldehyde|CS-B0224
      21172-41-8

    References

    • WO2012/7954 A1, ; Page/Page column 12 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   17.07
  • LogP   2.8369
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   3

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 21172-41-8 sigma21172-41-8 manufacturer21172-41-8 price21172-41-8 structure21172-41-8 SDSbuy 21172-41-821172-41-8 supplier21172-41-8 uses21172-41-8 molecular weightprice of 21172-41-821172-41-8 chemical name formula of 21172-41-8
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label