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3-Chloro-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

  • CAS No. 212651-52-0

  • Cat. No. CS-0208002
  • Purity≥97%
  • MDL No.MFCD00270534

*For research and further manufacturing use only, not for direct human use.

3-Chloro-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine|CS-0208002

Structure of 212651-52-0

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General Information

  • CAS No. 212651-52-0
  • Cat. No. CS-0208002
  • Purity ≥97%
  • MDL No. MFCD00270534
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₈H₁₆ClNO₄
  • Molecular Weight 345.78
  • Synonym(s) Fmoc-beta-chloro-L-alanine
  • SMILES ClC[C@@H](C(O)=O)NC(OCC1C2=CC=CC=C2C3=CC=CC=C31)=O

Description

This fluorenylmethoxycarbonyl-protected alanine derivative features a chlorinated side chain, enabling efficient incorporation into peptide chains during solid-phase synthesis. The C-terminal carbamate group provides orthogonal stability and selective deprotection under mild conditions, streamlining the assembly of complex peptides with high fidelity.

Synthesis

  • Route1

    References

    • Deboves; Montalbetti; Jackson Journal of the Chemical Society. Perkin Transactions 1, 2001 , # 16 p. 1876 - 1884

Safety Information

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GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H315-H318-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

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Computational Chemistry Data

  • TPSA   75.63
  • LogP   3.2171
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   5

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