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Structure of 21298-55-5
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2-(Thiophen-3-yl)pyridine features a fused heteroaromatic architecture combining thiophene and pyridine rings, delivering enhanced electron density at the 3-position. This configuration supports robust coordination in transition metal catalysis and facilitates π–π stacking in supramolecular assemblies. The molecule exhibits bench-stable handling and integrates readily into ligand design for palladium-catalyzed cross-coupling reactions.
2-(Thiophen-3-yl)pyridine serves as a versatile heterocyclic building block in medicinal chemistry and materials science, enabling efficient construction of biaryl scaffolds via palladium-catalyzed cross-coupling reactions. Its rigid, planar structure enhances π-stacking interactions in organic semiconductors and contributes to favorable binding geometry in kinase inhibitors. The molecule exhibits good bench stability, moderate solubility in common organic solvents, and tolerance to a range of functional groups, facilitating straightforward purification and integration into multi-step syntheses.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319
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Precautionary Statements : P264-P280-P302+P352-P362
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Lot numbers can be found on the outside label of a product: