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CS-W001157 4
Total: USD 88.00

Methyl prolinate hydrochloride

  • CAS No. 2133-40-6

  • Cat. No. CS-M0706
  • Purity≥97%
  • MDL No.MFCD00012708

*For research and further manufacturing use only, not for direct human use.

Methyl prolinate hydrochloride|CS-M0706

Structure of 2133-40-6

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General Information

  • CAS No. 2133-40-6
  • Cat. No. CS-M0706
  • Purity ≥97%
  • MDL No. MFCD00012708
  • Storage 4°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₂ClNO₂
  • Molecular Weight 165.62
  • Synonym(s) None
  • SMILES O=C(OC)[C@H]1NCCC1.Cl

Description

Methyl prolinate hydrochloride is a bench-stable, moisture-tolerant ester derivative of proline, featuring a protonated amine that enhances solubility in aqueous and polar organic media. This salt form simplifies handling and integration into synthetic workflows requiring stable, cationic building blocks.

Application

Methyl prolinate hydrochloride serves as a stable, bench-ready precursor for proline-derived scaffolds in peptide and heterocyclic synthesis. Its zwitterionic character enhances solubility and simplifies purification, while the methyl ester group enables selective derivatization under standard conditions. Functions effectively in coupling reactions and as a building block for cyclic peptides and bioactive analogs.

Synthesis

  • Route1

    References

    • Knudsen, Kristian Rahbek; Holden, John; Ley, Steven V.; Ladlow, Mark Advanced Synthesis and Catalysis, 2007 , vol. 349, # 4-5 p. 535 - 538
  • Route2
    • null|null
      67-56-1
    • L-Proline Enalapril  Impurity|CS-0229432
      147-85-3
    • ~99%
    • In-stock
      Methyl prolinate hydrochloride|CS-M0706
      2133-40-6

    References

    • Lewis, Arwel; Ryan, Martin D.; Gani, David Journal of the Chemical Society - Perkin Transactions 1, 1998 , # 22 p. 3767 - 3775
  • Route3
    • L-Proline Enalapril  Impurity|CS-0229432
      147-85-3
    • ~%
    • In-stock
      Methyl prolinate hydrochloride|CS-M0706
      2133-40-6

    References

    • US5424444 A1, ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.33
  • LogP   0.3332
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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