(R)-5-Methylpyrrolidin-2-one

Name: (R)-5-Methylpyrrolidin-2-one
Brand: ChemScene
Availability: InStock
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CAS No. 21395-93-7
Cat. No. CS-0046592
Purity≥98%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Description

(R)-5-Methylpyrrolidin-2-one is a chiral lactam featuring a stereodefined methyl group at the 5-position, enhancing its conformational rigidity. This bench-stable heterocycle serves as a privileged scaffold in medicinal chemistry, integrating readily into bioactive molecules through selective functionalization at the carbonyl and C5 sites.

Application

(R)-5-Methylpyrrolidin-2-one serves as a valuable chiral building block in medicinal chemistry, enabling efficient access to bioactive heterocycles. Its inherent stability and well-defined stereochemistry facilitate direct incorporation into complex scaffolds via nucleophilic substitution or reductive amination. The molecule exhibits excellent functional group tolerance and simplifies purification due to its crystalline nature, making it ideal for scalable synthesis and process development.

General Information

CAS No. 21395-93-7
Cat. No. CS-0046592
Purity ≥98%
MDL No. None
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₉NO
Molecular Weight 99.13
Synonym(s) (5R)-5-Methyl-2-pyrrolidinone
SMILES O=C1CC[C@@H](C)N1

Computational Chemistry Data

TPSA 29.1
LogP 0.2849
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P260-P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501

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Other Classifications

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Key Words

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(R)-5-Methylpyrrolidin-2-one

CAS No. 21395-93-7

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