(2R,4R)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)-4-hydroxypyrrolidine-2-carboxylic acid

Name: (2R,4R)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)-4-hydroxypyrrolidine-2-carboxylic acid
Brand: ChemScene
Availability: InStock
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CAS No. 214852-45-6
Cat. No. CS-0089869
Purity≥95%
MDL No.MFCD01318735

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(2R,4R)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)-4-hydroxypyrrolidine-2-carboxylic acid|CS-0089869

Structure of 214852-45-6

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Description

This fluorenylmethoxycarbonyl-protected pyrrolidine derivative features a stereodefined hydroxyl group at the C4 position, enabling direct incorporation into peptide synthesis. The bench-stable, moisture-tolerant scaffold facilitates efficient N-terminal functionalization in solid-phase and solution-phase workflows.

Application

(2R,4R)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)-4-hydroxypyrrolidine-2-carboxylic acid serves as a chiral building block for peptide synthesis and medicinal chemistry applications. The Fmoc group enables orthogonal protection, while the 4-hydroxy functionality provides a site for derivatization or incorporation into bioactive scaffolds. Bench-stable and readily purified by chromatography, it facilitates efficient coupling reactions in solid-phase and solution-phase workflows.

General Information

CAS No. 214852-45-6
Cat. No. CS-0089869
Purity ≥95%
MDL No. MFCD01318735
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₀H₁₉NO₅
Molecular Weight 353.37
Synonym(s) Fmoc-D-cis-hyp-OH
SMILES O=C(N1[C@@H](C(O)=O)C[C@@H](O)C1)OCC2C3=C(C4=C2C=CC=C4)C=CC=C3

Computational Chemistry Data

TPSA 87.07
LogP 2.4553
H_Acceptors 4
H_Donors 2
Rotatable_Bonds 3

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

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Other Classifications

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Life Science Amino Acids and their Derivatives Proline and derivatives

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Unnatural Amino Acid Derivatives

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(2R,4R)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)-4-hydroxypyrrolidine-2-carboxylic acid

CAS No. 214852-45-6

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