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CS-W001157 4
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6-Fluoro-2-iodopyridin-3-ol

  • CAS No. 214911-10-1

  • Cat. No. CS-0088333
  • Purity≥97%
  • MDL No.MFCD22392293

*For research and further manufacturing use only, not for direct human use.

6-Fluoro-2-iodopyridin-3-ol|CS-0088333

Structure of 214911-10-1

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General Information

  • CAS No. 214911-10-1
  • Cat. No. CS-0088333
  • Purity ≥97%
  • MDL No. MFCD22392293
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃FINO
  • Molecular Weight 238.99
  • Synonym(s) 6-Fluoro-3-hydroxy-2-iodopyridine
  • SMILES IC1=NC(F)=CC=C1O

Description

6-Fluoro-2-iodopyridin-3-ol features a strategically positioned iodine atom at the 2-position and a fluorine substituent at the 6-position on a pyridin-3-ol scaffold, enabling selective cross-coupling reactions. The phenolic hydroxyl group enhances solubility and provides a handle for derivatization. This compound serves as a key intermediate in the synthesis of bioactive heterocycles, particularly in medicinal chemistry and agrochemical development.

Application

6-Fluoro-2-iodopyridin-3-ol serves as a versatile building block in transition-metal-catalyzed cross-coupling reactions, enabling efficient C–C and C–heteroatom bond formation. The iodide group facilitates palladium- or nickel-mediated coupling with boronic acids, amines, and thiols, while the 3-hydroxyl and 6-fluoro substituents provide orthogonal reactivity and enhanced solubility. This compound exhibits bench stability and is compatible with standard purification protocols, making it well-suited for iterative synthesis of functionalized heterocycles and pharmaceutical intermediates.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   33.12
  • LogP   1.5309
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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