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Structure of 214911-10-1
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6-Fluoro-2-iodopyridin-3-ol features a strategically positioned iodine atom at the 2-position and a fluorine substituent at the 6-position on a pyridin-3-ol scaffold, enabling selective cross-coupling reactions. The phenolic hydroxyl group enhances solubility and provides a handle for derivatization. This compound serves as a key intermediate in the synthesis of bioactive heterocycles, particularly in medicinal chemistry and agrochemical development.
6-Fluoro-2-iodopyridin-3-ol serves as a versatile building block in transition-metal-catalyzed cross-coupling reactions, enabling efficient C–C and C–heteroatom bond formation. The iodide group facilitates palladium- or nickel-mediated coupling with boronic acids, amines, and thiols, while the 3-hydroxyl and 6-fluoro substituents provide orthogonal reactivity and enhanced solubility. This compound exhibits bench stability and is compatible with standard purification protocols, making it well-suited for iterative synthesis of functionalized heterocycles and pharmaceutical intermediates.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: