(6-chloro-3-pyridinyl)methanol

Name: (6-chloro-3-pyridinyl)methanol
Brand: ChemScene
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CAS No. 21543-49-7
Cat. No. CS-W002737
Purity≥97%
MDL No.MFCD01075226

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FedEx Limited Quantities Ground	$0.00
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(6-chloro-3-pyridinyl)methanol|CS-W002737

Structure of 21543-49-7

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Description

2-Chloro-5-hydroxymethylpyridine features a pyridine core functionalized with chlorine at the 2-position and a hydroxymethyl group at the 5-position, enabling direct coupling or derivatization in synthetic workflows. This bifunctional architecture supports efficient incorporation into pharmaceutical intermediates and ligand frameworks, where the hydroxymethyl moiety offers a site for further modification while maintaining compatibility with standard reaction conditions.

Application

2-Chloro-5-hydroxymethylpyridine serves as a versatile building block in medicinal chemistry, enabling site-specific functionalization via the reactive chloro and hydroxymethyl groups. The hydroxymethyl moiety facilitates direct oxidation to carboxylic acid or ether formation, while the chlorine supports palladium-catalyzed cross-coupling reactions. Its bench-stable nature and compatibility with common protecting group strategies make it ideal for constructing heterocyclic scaffolds and API intermediates in multi-step syntheses.

General Information

CAS No. 21543-49-7
Cat. No. CS-W002737
Purity ≥97%
MDL No. MFCD01075226
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₆ClNO
Molecular Weight 143.57
Synonym(s) 2-Chloro-5-(hydroxymethyl)pyridine
SMILES OCc1ccc(nc1)Cl

Computational Chemistry Data

TPSA 33.12
LogP 1.2273
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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(6-chloro-3-pyridinyl)methanol

CAS No. 21543-49-7

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