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CS-W001157 4
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7-Bromo-5-chloroindolin-2-one

  • CAS No. 215433-19-5

  • Cat. No. CS-0187255
  • Purity≥96%
  • MDL No.None
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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*For research and further manufacturing use only, not for direct human use.

7-Bromo-5-chloroindolin-2-one|CS-0187255

Structure of 215433-19-5

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Description

7-Bromo-5-chloroindolin-2-one features a fused tricyclic core with halogenated substituents at the 7 and 5 positions, imparting enhanced electron-withdrawing character. This configuration supports stable integration into synthetic scaffolds for medicinal chemistry campaigns, particularly in kinase inhibitor development and bioactive heterocycle design.

Application

7-Bromo-5-chloroindolin-2-one serves as a versatile building block in medicinal chemistry, enabling efficient access to substituted indole scaffolds. Its bromo and chloro substituents provide orthogonal handles for palladium-catalyzed cross-coupling reactions, while the ketone functionality supports enolate formation and electrophilic substitution. Bench-stable and readily purified by recrystallization, it functions effectively in multi-step syntheses of bioactive heterocycles and API intermediates.

General Information

  • CAS No. 215433-19-5
  • Cat. No. CS-0187255
  • Purity ≥96%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₅BrClNO
  • Molecular Weight 246.49
  • Synonym(s) 7-BROMO-5-CHLORO-2-OXINDOLE
  • SMILES ClC=1C=C2CC(NC2=C(C1)Br)=O

Computational Chemistry Data

  • TPSA   29.1
  • LogP   2.5971
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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