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CS-W001157 4
Total: USD 88.00

6-Bromo-3H-oxazolo[4,5-b]pyridin-2-one

  • CAS No. 21594-52-5

  • Cat. No. CS-W003545
  • Purity≥97%
  • MDL No.MFCD08689590

*For research and further manufacturing use only, not for direct human use.

6-Bromo-3H-oxazolo[4,5-b]pyridin-2-one|CS-W003545

Structure of 21594-52-5

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General Information

  • CAS No. 21594-52-5
  • Cat. No. CS-W003545
  • Purity ≥97%
  • MDL No. MFCD08689590
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃BrN₂O₂
  • Molecular Weight 215.00
  • Synonym(s) T56 BO DN FNJ CQ HE
  • SMILES Brc1cc2oc(=O)[nH]c2nc1

Description

6-Bromo-3H-oxazolo[4,5-b]pyridin-2-one is a heterocyclic building block featuring a brominated oxazolopyridinone core. This scaffold integrates a reactive halogen site with a stable, electron-deficient ring system, enabling direct coupling in cross-coupling reactions. The compound exhibits excellent bench stability and solubility in common organic solvents, facilitating use in synthetic workflows for pharmaceutical intermediates and functional materials.

Application

6-Bromo-3H-oxazolo[4,5-b]pyridin-2-one serves as a versatile heterocyclic building block for medicinal chemistry and materials science applications. Its bromine substituent enables palladium-catalyzed cross-coupling reactions, while the oxazolopyridinone core offers structural rigidity and hydrogen-bonding capability. The compound exhibits bench stability, facilitates straightforward purification, and functions effectively in Suzuki, Stille, and Negishi coupling protocols.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   58.89
  • LogP   1.2786
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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