5'(E)-VP-2'-OMe-U phosphoramidite

Name: 5'(E)-VP-2'-OMe-U phosphoramidite
Brand: ChemScene
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CAS No. 2172373-55-4
Cat. No. CS-0907394
Purity≥98%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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5'(E)-VP-2'-OMe-U phosphoramidite|CS-0907394

Structure of 2172373-55-4

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Description

This phosphorylated diester integrates a cyanoethoxy-diisopropylamino phosphino group with a pyrimidinone-bearing tetrahydrofuran core, enabling efficient coupling in nucleoside analog synthesis. The molecule exhibits robust stability under standard bench conditions and facilitates selective phosphoramidate formation through its dual ester functionalities.

Application

This compound serves as a protected phosphoramidite building block for oligonucleotide synthesis, enabling efficient coupling in solid-phase DNA and RNA assembly. The cyanoethoxy-dimethylaminophosphino group facilitates rapid deprotection, while the dimethylpropanoate esters ensure bench stability and ease of purification. Its structure supports high-yielding, regioselective phosphotriester formation under standard conditions, making it ideal for scalable nucleic acid synthesis workflows.

General Information

CAS No. 2172373-55-4
Cat. No. CS-0907394
Purity ≥98%
MDL No. None
Storage 4°C, protect from light, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₃₂H₅₂N₄O₁₃P₂
Molecular Weight 762.72
Synonym(s) None
SMILES CO[C@@H]1[C@H](OP(OCCC#N)N(C(C)C)C(C)C)[C@@H](/C=C/P(OCOC(C(C)(C)C)=O)(OCOC(C(C)(C)C)=O)=O)O[C@H]1N2C=CC(NC2=O)=O

Computational Chemistry Data

TPSA 206.94
LogP 4.94378
H_Acceptors 16
H_Donors 1
Rotatable_Bonds 18

Safety Information

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GHS Pictogram : N/A	GHS No : N/A
Signal Word : N/A	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : N/A
Precautionary Statements : N/A

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Other Classifications

Life Science Nucleosides & Nucleotides

Key Words

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5'(E)-VP-2'-OMe-U phosphoramidite

CAS No. 2172373-55-4

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