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Structure of 21784-73-6
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4-Iodo-2-nitrophenol features a para-iodo and ortho-nitro substitution on the phenolic ring, creating a highly functionalized aromatic scaffold. This arrangement enables direct coupling in cross-coupling reactions and facilitates downstream derivatization. The molecule exhibits enhanced reactivity due to the electron-withdrawing nitro group adjacent to the hydroxyl, while the iodine serves as a robust handle for palladium-catalyzed transformations. Bench-stable and moisture-tolerant, it supports reliable use in synthetic workflows requiring precision and reproducibility.
4-Iodo-2-nitrophenol serves as a versatile building block in the synthesis of functionalized heterocycles and pharmaceutical intermediates. The iodine group enables palladium-catalyzed cross-coupling reactions, while the ortho-nitro group facilitates selective reductions and subsequent cyclizations. Its stability under standard bench conditions and compatibility with diverse reaction protocols make it a practical choice for medicinal chemistry and process development workflows.
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GHS Pictogram :
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GHS No : GHS05,GHS07,GHS09
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Signal Word : Danger
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UN#: 3077
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Class : 9
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Packing Group : Ⅲ
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Hazard Statements : H302-H315-H317-H318-H410
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Precautionary Statements : P261-P264-P270-P272-P273-P280-P302+P352-P330-P362+P364-P391-P501
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Lot numbers can be found on the outside label of a product: