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CS-W001157 4
Total: USD 88.00

N-Mal-N-bis(PEG2-NHS ester)

  • CAS No. 2182601-73-4

  • Cat. No. CS-0115088
  • Purity≥98%
  • MDL No.MFCD29912828
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

N-Mal-N-bis(PEG2-NHS ester)|CS-0115088

Structure of 2182601-73-4

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Description

N-Mal-N-bis(PEG2-NHS ester) delivers a dual reactive handle for site-specific conjugation, combining maleimide’s affinity for thiols with NHS ester’s reactivity toward amines. This bifunctional linker enables efficient, orthogonal coupling in biomolecule labeling and protein-polymer hybrid synthesis under physiological conditions.

Application

N-Mal-N-bis(PEG2-NHS ester) serves as a bifunctional crosslinker enabling efficient conjugation of maleimide-reactive thiol groups with amine-containing biomolecules. The PEG2 spacer enhances solubility and reduces steric hindrance, while the NHS ester moiety facilitates rapid coupling to primary amines under physiological conditions. This reagent offers excellent stability in aqueous buffers and simplifies purification due to its hydrophilic nature, making it ideal for site-specific bioconjugation in antibody-drug conjugate (ADC) development and protein labeling workflows.

General Information

  • CAS No. 2182601-73-4
  • Cat. No. CS-0115088
  • Purity ≥98%
  • MDL No. MFCD29912828
  • Storage -20°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₉H₃₈N₄O₁₅
  • Molecular Weight 682.63
  • Synonym(s) None
  • SMILES O=C(ON1C(CCC1=O)=O)CCOCCOCCN(C(CCN2C(C=CC2=O)=O)=O)CCOCCOCCC(ON3C(CCC3=O)=O)=O

Computational Chemistry Data

  • TPSA   221.97
  • LogP   -1.8089
  • H_Acceptors   15
  • H_Donors   0
  • Rotatable_Bonds   23

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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