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Structure of 2182601-73-4
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N-Mal-N-bis(PEG2-NHS ester) delivers a dual reactive handle for site-specific conjugation, combining maleimide’s affinity for thiols with NHS ester’s reactivity toward amines. This bifunctional linker enables efficient, orthogonal coupling in biomolecule labeling and protein-polymer hybrid synthesis under physiological conditions.
N-Mal-N-bis(PEG2-NHS ester) serves as a bifunctional crosslinker enabling efficient conjugation of maleimide-reactive thiol groups with amine-containing biomolecules. The PEG2 spacer enhances solubility and reduces steric hindrance, while the NHS ester moiety facilitates rapid coupling to primary amines under physiological conditions. This reagent offers excellent stability in aqueous buffers and simplifies purification due to its hydrophilic nature, making it ideal for site-specific bioconjugation in antibody-drug conjugate (ADC) development and protein labeling workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: