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Structure of 219763-83-4
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4-Chloroquinoline-6-carbonitrile features a fused bicyclic core with complementary electron-withdrawing nitrile and chloro substituents at the 6- and 4-positions, respectively. This arrangement enhances its utility in transition metal-catalyzed cross-coupling reactions and as a building block for bioactive heterocycles. The molecule exhibits robust stability under standard conditions and facilitates efficient derivatization in synthetic medicinal chemistry workflows.
4-Chloroquinoline-6-carbonitrile serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the 2- and 8-positions via palladium-catalyzed cross-coupling reactions. Its chlorine and nitrile groups provide orthogonal reactivity for late-stage diversification, while its bench-stable crystalline nature facilitates handling and purification. Functions as a key scaffold for kinase inhibitors and other bioactive heterocycles.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: