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Structure of 219873-06-0
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3-Fluoro-4-(hydroxymethyl)benzonitrile features a strategically positioned nitrile group and hydroxymethyl moiety on a fluorinated aromatic ring, enabling selective functionalization in medicinal chemistry. The electron-withdrawing fluorine enhances reactivity at the para-position, while the hydroxymethyl group offers a handle for derivatization under standard conditions. This scaffold supports rapid access to bioactive compounds in drug discovery workflows.
3-Fluoro-4-(hydroxymethyl)benzonitrile serves as a versatile building block in medicinal chemistry, enabling efficient access to bioactive heterocycles and pharmaceutical intermediates. The nitrile group facilitates transformations such as amidation or reduction, while the hydroxymethyl function supports oxidation to carboxylic acid or derivatization via Mitsunobu reactions. Its fluorinated aromatic core enhances metabolic stability and modulates electronic properties, making it well-suited for drug discovery applications requiring precise functional group placement and synthetic flexibility.
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GHS Pictogram :
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GHS No : GHS05
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Signal Word : Danger
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UN#: 3261
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Class : 8
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Packing Group : Ⅲ
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Hazard Statements : H318
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Precautionary Statements : P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P363-P405-P501
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Lot numbers can be found on the outside label of a product: