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Structure of 220141-23-1
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Methyl 4-fluoro-2-(trifluoromethyl)benzoate features a fluorinated aromatic core with orthogonal electron-withdrawing groups, enabling enhanced electrophilicity at the carbonyl center. This sterically accessible ester integrates readily into cross-coupling and nucleophilic substitution workflows, offering high functional group tolerance under standard conditions.
Methyl 4-fluoro-2-(trifluoromethyl)benzoate serves as a versatile building block in medicinal chemistry, enabling efficient access to fluorinated aromatic scaffolds. Its orthogonal reactivity profile—combining electrophilic fluorine and strongly electron-withdrawing trifluoromethyl groups—facilitates palladium-catalyzed cross-coupling, nucleophilic substitution, and directed ortho-metalation. The methyl ester provides a stable, bench-ready handle for downstream functionalization, with excellent purity and reproducibility in scale-up processes.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: