2,4,6-Trifluorobenzene-1-sulfonyl chloride

Name: 2,4,6-Trifluorobenzene-1-sulfonyl chloride
Brand: ChemScene
Availability: InStock
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CAS No. 220239-64-5
Cat. No. CS-W010371
Purity≥98%
MDL No.MFCD01091015

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2,4,6-Trifluorobenzene-1-sulfonyl chloride|CS-W010371

Structure of 220239-64-5

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Application

2,4,6-Trifluorobenzene-1-sulfonyl chloride serves as a highly effective sulfonylating agent for the synthesis of sulfonamide derivatives. Its electron-deficient aromatic ring enhances reactivity while maintaining bench stability, enabling efficient coupling with amines under mild conditions. The trifluoromethyl group imparts excellent functional group tolerance and facilitates purification via crystallization or chromatography. This reagent functions reliably in the construction of bioactive scaffolds and pharmaceutical intermediates where enhanced metabolic stability is required.

General Information

CAS No. 220239-64-5
Cat. No. CS-W010371
Purity ≥98%
MDL No. MFCD01091015
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₂ClF₃O₂S
Molecular Weight 230.59
Synonym(s) 2,4,6-trifluorobenzenesulfonyl Chloride
SMILES O=S(C1=C(F)C=C(F)C=C1F)(Cl)=O

Computational Chemistry Data

TPSA 34.14
LogP 2.0314
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 1

Safety Information

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GHS Pictogram :	GHS No : GHS05
Signal Word : Danger	UN#: 3265
Class : 8	Packing Group : Ⅱ
Hazard Statements : H314
Precautionary Statements : P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

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Other Classifications

Building Blocks Functional Group Sulfonyl Chloride

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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2,4,6-Trifluorobenzene-1-sulfonyl chloride

CAS No. 220239-64-5

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