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Structure of 220943-23-7
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5-Fluoro-1H-indole-2-carbaldehyde features a fluorinated indole core with an aldehyde at the 2-position, enabling direct coupling in cross-coupling and condensation reactions. The electron-deficient carbonyl group enhances reactivity in nucleophilic additions, while the fluorine substituent imparts metabolic stability and modulates electronic properties. This bench-stable compound serves as a key intermediate for bioactive heterocycles.
5-Fluoro-1H-indole-2-carbaldehyde serves as a versatile building block for the synthesis of fluorinated heterocycles and bioactive molecules. Its aldehyde functionality enables efficient coupling reactions, including reductive amination and Wittig transformations, while the 5-fluoro substitution enhances metabolic stability and modulates electronic properties. The compound exhibits excellent bench stability and is compatible with standard purification techniques, facilitating integration into medicinal chemistry and process development workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H319
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Precautionary Statements : P264-P280-P305+P351+P338-P337+P313
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Lot numbers can be found on the outside label of a product: