Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

2-(Difluoromethoxy)-6-fluorobenzonitrile

  • CAS No. 221202-14-8

  • Cat. No. CS-0182137
  • Molecule weight187.12
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-(Difluoromethoxy)-6-fluorobenzonitrile|CS-0182137

Structure of 221202-14-8

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 221202-14-8
  • Cat. No. CS-0182137
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₄F₃NO
  • Molecular Weight 187.12
  • Synonym(s) 2-(Difluoromethoxy)-6-fluoro-benzonitrile
  • SMILES N#CC1=C(F)C=CC=C1OC(F)F

Description

2-(Difluoromethoxy)-6-fluorobenzonitrile features a strategically positioned nitrile group flanked by fluorine and difluoromethoxy substituents, delivering enhanced electron-withdrawing character and metabolic stability. This trifunctional aromatic core integrates readily into pharmaceutical intermediates, offering improved solubility and robustness under standard bench conditions.

Application

2-(Difluoromethoxy)-6-fluorobenzonitrile serves as a versatile building block in medicinal chemistry, enabling the synthesis of fluorinated aromatic scaffolds via standard coupling reactions. Its ortho-fluoro and difluoromethoxy substituents provide enhanced metabolic stability and modulated lipophilicity, while the nitrile group facilitates downstream transformations including hydrolysis to carboxylic acids or reduction to primary amines. The compound exhibits good bench stability and compatibility with common reaction conditions, supporting efficient route development for bioactive molecules.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H311-H331
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361+P364-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   33.02
  • LogP   2.29878
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   2

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 2-(Difluoromethoxy)-6-fluorobenzonitrile sigma2-(Difluoromethoxy)-6-fluorobenzonitrile manufacturer2-(Difluoromethoxy)-6-fluorobenzonitrile price2-(Difluoromethoxy)-6-fluorobenzonitrile structure2-(Difluoromethoxy)-6-fluorobenzonitrile SDSbuy 2-(Difluoromethoxy)-6-fluorobenzonitrile2-(Difluoromethoxy)-6-fluorobenzonitrile supplier2-(Difluoromethoxy)-6-fluorobenzonitrile uses2-(Difluoromethoxy)-6-fluorobenzonitrile molecular weightprice of 2-(Difluoromethoxy)-6-fluorobenzonitrile2-(Difluoromethoxy)-6-fluorobenzonitrile chemical name formula of 2-(Difluoromethoxy)-6-fluorobenzonitrile
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label