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CS-W001157 4
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tert-Butyl (S)-3-(3-(2,2-dimethoxyethyl)ureido)-2-(4-fluoro-3,5-dimethylphenyl)-4-methyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxylate

  • CAS No. 2212021-60-6

  • Cat. No. CS-0619767
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

tert-Butyl (S)-3-(3-(2,2-dimethoxyethyl)ureido)-2-(4-fluoro-3,5-dimethylphenyl)-4-methyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxylate|CS-0619767

Structure of 2212021-60-6

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General Information

  • CAS No. 2212021-60-6
  • Cat. No. CS-0619767
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₅H₃₆FN₅O₅
  • Molecular Weight 505.58
  • Synonym(s) None
  • SMILES COC(OC)CNC(NC1=C2C(CCN([C@H]2C)C(OC(C)(C)C)=O)=NN1C3=CC(C)=C(C(C)=C3)F)=O

Description

This tetrahydro-pyrazolopyridine derivative features a tert-butyl ester group and a fluoro-substituted aryl moiety, enabling precise tuning of solubility and metabolic stability. The 2,2-dimethoxyethylureido side chain enhances polarity and hydrogen-bonding capacity, while the sterically protected methyl groups contribute to conformational rigidity. This scaffold integrates well into medicinal chemistry campaigns targeting kinase inhibition and CNS-penetrant therapeutics under standard bench conditions.

Application

tert-Butyl (S)-3-(3-(2,2-dimethoxyethyl)ureido)-2-(4-fluoro-3,5-dimethylphenyl)-4-methyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxylate serves as a versatile building block for the synthesis of pyrazolopyridine-based scaffolds. Its tert-butyl ester enables straightforward deprotection under mild acidic conditions, while the 2,2-dimethoxyethyl ureido group provides orthogonal handle for selective functionalization. The molecule exhibits robust bench stability and compatibility with standard coupling reactions, facilitating efficient access to biologically relevant heterocycles in medicinal chemistry campaigns.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   106.95
  • LogP   4.22284
  • H_Acceptors   7
  • H_Donors   2
  • Rotatable_Bonds   6

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