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Structure of 22123-14-4
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2-Chloro-6-methyl-4-(trifluoromethyl)pyridine is a fluorinated heterocyclic scaffold featuring orthogonal reactivity at the chloro and trifluoromethyl positions. This electron-deficient pyridine integrates readily into cross-coupling reactions, enabling efficient access to functionalized aromatic systems under standard conditions. The methyl group enhances solubility and provides a handle for further derivatization.
2-Chloro-6-methyl-4-(trifluoromethyl)pyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its reactive C–Cl bond and electron-deficient pyridine core. The trifluoromethyl group enhances metabolic stability and lipophilicity, while the methyl substituent provides steric and electronic modulation. Its bench-stable nature and compatibility with standard reaction conditions facilitate efficient synthesis of complex heterocyclic scaffolds relevant to pharmaceutical development.
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GHS Pictogram :
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GHS No : GHS06
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Signal Word : Danger
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UN#: 2810
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H301
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: