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CS-W001157 4
Total: USD 88.00

Fmoc-PEG12-NHS ester

  • CAS No. 2227246-92-4

  • Cat. No. CS-0115161
  • Purity≥97%
  • MDL No.MFCD21363319

*For research and further manufacturing use only, not for direct human use.

Fmoc-PEG12-NHS ester|CS-0115161

Structure of 2227246-92-4

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General Information

  • CAS No. 2227246-92-4
  • Cat. No. CS-0115161
  • Purity ≥97%
  • MDL No. MFCD21363319
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄₆H₆₈N₂O₁₈
  • Molecular Weight 937.03
  • Synonym(s) None
  • SMILES O=C(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(ON4C(CCC4=O)=O)=O

Description

Fmoc-PEG12-NHS ester enables efficient conjugation in aqueous environments, combining the robust anchoring of NHS ester reactivity with the solubility and flexibility of a 12-mer PEG spacer. This bifunctional linker integrates seamlessly into peptide synthesis workflows, delivering enhanced stability and reduced aggregation during bioconjugation.

Application

Fmoc-PEG12-NHS ester serves as a versatile bifunctional linker for peptide and protein conjugation, combining the orthogonal protection of Fmoc with the reactive NHS ester for amine coupling. The 12-ethylene glycol spacer provides enhanced solubility and flexibility, minimizing steric interference in bioconjugation workflows. This reagent enables efficient, site-specific labeling under physiological conditions and is compatible with standard purification methods, making it ideal for synthesizing peptide-drug conjugates and biomolecular probes.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   212.77
  • LogP   2.7216
  • H_Acceptors   18
  • H_Donors   1
  • Rotatable_Bonds   42

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