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CS-W001157 4
Total: USD 88.00

(2S,4R)-N-(2,6-Dimethylphenyl)-4-hydroxypyrrolidine-2-carboxamide

  • CAS No. 2227488-62-0

  • Cat. No. CS-0752391
  • Purity≥97%
  • MDL No.None
  • HazMat Fee +

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    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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*For research and further manufacturing use only, not for direct human use.

(2S,4R)-N-(2,6-Dimethylphenyl)-4-hydroxypyrrolidine-2-carboxamide|CS-0752391

Structure of 2227488-62-0

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Description

This chiral pyrrolidine derivative features a hydroxyl group at C4 and an amide linkage to a 2,6-dimethylphenyl moiety, offering enhanced solubility and stability under standard conditions. The stereochemistry at C2 and C4 enables precise molecular recognition in asymmetric synthesis and medicinal chemistry applications.

Application

(2S,4R)-N-(2,6-Dimethylphenyl)-4-hydroxypyrrolidine-2-carboxamide serves as a versatile chiral building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles and peptidomimetics. The hydroxypyrrolidine core provides a rigid, stereodefined scaffold with hydrogen-bonding capacity, while the N-aryl substitution enhances metabolic stability and modulates solubility. Its bench-stable nature and compatibility with standard coupling and functionalization reactions facilitate efficient route development for API candidates.

General Information

  • CAS No. 2227488-62-0
  • Cat. No. CS-0752391
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₁₈N₂O₂
  • Molecular Weight 234.29
  • Synonym(s) None
  • SMILES CC1=CC=CC(C)=C1NC(=O)[C@@H]1C[C@@H](O)CN1

Computational Chemistry Data

  • TPSA   61.36
  • LogP   0.96474
  • H_Acceptors   3
  • H_Donors   3
  • Rotatable_Bonds   2

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P305+P351+P338-P362+P364

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