Thalidomide-1-Me,5-F

Name: Thalidomide-1-Me,5-F
Brand: ChemScene
Availability: InStock
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CAS No. 2230957-36-3
Cat. No. CS-0617311
Purity≥98%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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*For research and further manufacturing use only, not for direct human use.

Structure of 2230957-36-3

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Description

Thalidomide-1-Me,5-F features a methylated C1 position and a fluorinated C5 site, enhancing metabolic stability and modulating electronic properties. This derivative maintains the core phthalimide scaffold with improved resistance to degradation under physiological conditions. The strategic substitution pattern supports sustained bioactivity in targeted therapeutic applications.

Application

Thalidomide-1-Me,5-F serves as a well-defined analog for probing structure-activity relationships in immunomodulatory imide (IMiD) pharmacophores. Its methyl substitution at C1 and fluorine at C5 enhances metabolic stability while preserving core reactivity for targeted protein degradation studies. Functions as a bench-stable building block in medicinal chemistry campaigns focused on cereblon-binding scaffolds, enabling direct comparison with parent thalidomide in functional assays.

General Information

CAS No. 2230957-36-3
Cat. No. CS-0617311
Purity ≥98%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₄H₁₁FN₂O₄
Molecular Weight 290.25
Synonym(s) None
SMILES O=C1N(C(CC2)C(N(C)C2=O)=O)C(C3=C1C=CC(F)=C3)=O

Computational Chemistry Data

TPSA 74.76
LogP 0.5691
H_Acceptors 4
H_Donors 0
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07,GHS08
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H312-H332-H361
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Functional Group Amide

Building Blocks Skeleton Aromatic heterocycle compounds Indolin compounds

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Key Words

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Thalidomide-1-Me,5-F

CAS No. 2230957-36-3

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