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Structure of 22398-14-7
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Dimethyl 2-(methoxymethylene)malonate features a highly reactive methoxymethylene group flanked by two ester functionalities, enabling efficient participation in [4+2] cycloadditions and Mannich-type reactions. This electron-deficient dienophile integrates readily into synthetic sequences requiring controlled C–C bond formation under mild conditions.
Dimethyl 2-(methoxymethylene)malonate serves as a versatile synthon in heterocyclic synthesis, enabling efficient construction of pyrrolidine and furan scaffolds via condensation and cycloaddition reactions. Its stabilized enolizable methoxymethylene group facilitates controlled Michael additions and Knoevenagel-type condensations, while the dimethyl malonate framework provides excellent functional group tolerance and bench stability. The compound is particularly useful in medicinal chemistry for accessing bioactive core structures with predictable reactivity profiles.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319
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Precautionary Statements : P264-P270-P280-P302+P352-P330-P362+P364-P501
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Lot numbers can be found on the outside label of a product: